Molecular Profiling of Multiple Myeloma Running Head: Molecular Analysis of Myeloma Section: Neoplasia
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Multiple myeloma in a patient with suspected hyperparathyroidism
Multiple myeloma (MM) is a clonal B-lymphocyte neoplasm of terminally differentiated plasma cells. Imaging modalities which allow the recognition of the effects of myeloma cells on the skeletal system have been utilized for a long time. Herein, we represent a patient with generalized osteoporosis and hypercalcemia, who was referred for parathyroid scan, in whom the widespread bone marrow techne...
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Cytogenetic abnormalities are important clinical parameters in various types of cancer, including multiple myeloma. We developed a model to predict cytogenetic abnormalities in patients with multiple myeloma using gene expression profiling and validated it by different cytogenetic techniques. The model has an accuracy rate up to 0.89. These results provide proof of concept for the hypothesis th...
متن کاملHypodiploid multiple myeloma is characterized by more aggressive molecular markers than non-hyperdiploid multiple myeloma.
Multiple myeloma can be categorized into hyperdiploid or non-hyperdiploid myeloma based on the number of chromosomes found in the tumor clone. Among the non-hyperdiploid myelomas, the hypodiploid subtype has the most aggressive clinical phenotype, but the genetic differences between groups are not completely defined. In order to understand the genetic background of hypodiploid multiple myeloma ...
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Running Head: Inhibition of multiple myeloma by DMC. Scientific Heading: Neoplasia
متن کاملRunning head GOLDEN et al. GREEN TEA NEUTRALIZES BORTEZOMIB THERAPY Journal section designation MYELOID NEOPLASIA Title Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid- based proteasome inhibitors Bylines
GOLDEN et al. GREEN TEA NEUTRALIZES BORTEZOMIB THERAPY Journal section designation MYELOID NEOPLASIA Title Green tea polyphenols block the anticancer effects of bortezomib and other boronic acidbased proteasome inhibitors Bylines Encouse B. Golden, Philip Y. Lam, Adel Kardosh, Kevin J. Gaffney, Enrique Cadenas, Stan G. Louie, Nicos A. Petasis, Thomas C. Chen, Axel H. Schönthal Affiliation lines...
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تاریخ انتشار 2001